Endocrine Abstracts

Background: Hypocaloric diets reduce the risk for type 2 diabetes (T2D) in obese subjects. However, there is a large inter-subject variability in the response to these interventions. The factors affecting this variability remain poorly understood. We and others reported that high plasma apoB-lipoproteins predict risk factors for, and incidence of, T2D in obese subjects independent of adiposity or fat distribution.Objective: To test the hypothesis that pl...

Background: Elevated plasma concentrations of apoB-lipoproteins (i.e. hyperapoB) is an independent predictor of type 2 diabetes (T2D) in humans; however underlying mechanisms remain unclear. Chronic reduction in the function of white adipose tissue (WAT) promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL, the most common form of apoB-lipoproteins, induce their dysfunction, measured as decreased hydrolysis and storage of t...